She stated that the role of Dani helped her to grow comfortable towards playing darker roles in the horror and thriller genres, later stating that she has "got a knack for" them.
Screen Rant wrote in 2021 that "if there is any performance that has absolutely been a star-making one, one would need look no further than Victoria Pedretti's incredible work." For her performance, she earned a nomination from the Critics' Choice Super Awards and won the award for Best Frightened Performance at the 2021 MTV Movie & TV Awards. Pedretti was next announced to lead the follow-up season to Hill House, later revealed to be titled The Haunting of Bly Manor, which was released in 2020 to positive reception.
In 2020, Pedretti guest-starred in the anthology series Amazing Stories as Evelyn Porter, and in the same year starred as Katherine in the biographical-drama film Shirley, the latter of which received positive reviews from critics. Also in 2019, Pedretti appeared as Leslie Van Houten in Quentin Tarantino's comedy-drama film Once Upon a Time in Hollywood, which was a commercial success, and earned her a nomination for the Critics' Choice Movie Award for Best Acting Ensemble. The second season was released by Netflix on December 26, 2019, with Pedretti's performance and the show being received positively. Pedretti auditioned for the role of Guinevere Beck on the thriller series You although she was rejected, the directors later cast her as Love Quinn in the show's second season after seeing her previous acting work and her chemistry with her co-star Penn Badgley. This is one of the defining roles for Victoria Pedretti, and she's only getting started." Dakota Moss of MovieWeb wrote that "Pedretti's emotions to the role add a horrifying realism to the character, and viewers can feel all of Nell's pain and anguish to the very end. She was lauded for her performance, and earned Saturn Award and MTV Award nominations in 2019 she was promptly established as a modern-day scream queen. Pedretti rose to prominence for her role on Netflix's 2018 series The Haunting of Hill House, where she played Eleanor "Nell" Crain Vance. Maybe you should try directing.' And I was like, 'That's not easier.'" Career
She revealed in a 2020 interview that she was told by her Carnegie Mellon teachers not to pursue acting: "They were like, 'I don't know if you're cut out for this. Pedretti attended Pennsbury High School in Fairless Hills, where she expressed an interest in musical theatre, and the Carnegie Mellon School of Drama in Pittsburgh, where she earned a BFA in acting in 2017. She was diagnosed with ADHD when she was six years old. She has said that she grew up in an emotionally abusive household, but said of her parents that she "love them very much and they tried their best".
Three of her father's four grandparents were Italian, while her maternal grandmother was Ashkenazi Jewish. Pedretti was born in Philadelphia on March 23, 1995.